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Q: "How do we know there really is a God?"
A: The answer to this question starts not in a person¡¯s head, but in their heart. "Do I really want to know¡­. or am I asking this just to avoid meeting God?" If a person is really seeking the truth, then there are some very valid reasons for believing in the reality of God. If not, there will probably never be enough proof to satisfy them. For the sincere seeker, here are some ideas. (Note: The Bible never argues for the existence of God, it simply assumes it.) We know there is a God for several reasons¡­.

Nothing in this world is able to explain its own existence; thus, there must be a Supreme Being in order to explain the world in which we find ourselves. (If there is a creation, there must be a Creator. Romans 1:20).  (Theologians call this the "Cosmological Argument".) 
The characteristics of the universe and life on our planet are so intricate that the idea of chance or coincidence being the means by which such intricacy developed is laughable. If you would never assume all the pieces of a jigsaw puzzle could assemble themselves by just shaking the box, why would you assume that such amazing order and organization in the physical world occurred by means of random events. (If there is a design, there must be a Designer. Romans 2:4). (Theologians call this the "Teleological Argument".) 
People¡¯s own hearts tells them that there is a God¡­.. otherwise they would not have asked the question in the first place. There is a basic inborn "guidance system" within every person of every culture and time period that enables them to sense right/wrong, fair/unfair, good/bad. This is far beyond a physical mechanism. It is the implanting of an inner sense of "law" that must have been given by a greater mind. (If there is a law, there must be a Lawgiver. Romans 2:14-16). (Theologians call this the "Moral Argument".) 
You can¡¯t explain Jesus Christ unless God exists. The life, words, and works of Jesus are well documented in history for the honest researcher to see. If He was a real person, then it is crucial to determine the truthfulness of His claim (that He was the divine Son of God¡­ indicating the reality of God, Himself). Jesus even said (in John 14:7-11) that His own reality was inseparable from that of God¡¯s. Jesus Christ (using the logic of C. S. Lewis) was either a legend, a liar, a lunatic¡­ or the Lord that He claimed to be. And if His claims stand up, then there must be a God, existing as the ultimate Reality.